A proprietary extract from black pepper (Piper nigrum) called BioPerine® is frequently utilized in dietary supplements because it has the potential to increase the bioavailability and effectiveness of other bioactive substances. The body’s ability to absorb and process a variety of nutrients and medications is known to be enhanced by BioPerine®. It is also acknowledged for its potential to provide health advantages like anti-inflammatory, antioxidant, and thermogenic properties. Moreover, BioPerine® is increasingly well-liked among students, athletes, and professionals seeking cognitive enhancement as a nootropic supplement that may enhance memory, learning ability, and cognition.
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Nature of BioPerine®
Black pepper’s primary alkaloid, piperine, is the subject of the standardized extract BioPerine®, which contains at least 95% piperine. The pungent substance piperine gives black pepper and other piper species, like long pepper (Piper longum) and white pepper (Piper nigrum), their spiciness. Although piperine and capsaicin, the main ingredient in chili peppers, have similar chemical structures, they differ pharmacologically. Capsaicin has a short half-life, low bioavailability, and poor water solubility while piperine is the vice versa. Hence, piperine is generally well-taken as a dietary supplement.
Health Benefits of BioPerine®
Several possible health advantages of BioPerine® have been demonstrated, including:
1. Anti-inflammatory Properties: Studies have shown that piperine inhibits the production of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2), which are linked to many chronic diseases like diabetes, cancer, and cardiovascular disease.
2. Antioxidant Effects: Studies have demonstrated that piperine can scavenge free radicals and boost the activity of antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT), which shield cells from oxidative stress and damage.
3. Thermogenic Effects: It has been demonstrated that piperine increases thermogenesis, the body’s generation of heat, by triggering the transient receptor potential vanilloid type 1 (TRPV1) and arousing the sympathetic nervous system. Weight reduction may result from increased energy use and fat oxidation.
4. Impacts on Nutrient Absorption: Studies have demonstrated that BioPerine® increases the plasma concentration and duration of several nutrients and supplements, including curcumin, resveratrol, vitamin C, vitamin B6, and coenzyme Q10. This is done by preventing their metabolism.
5. Nootropic Effects: It has been demonstrated that BioPerine® improves cognitive performance and memory by speeding up the metabolism of other nootropic supplements including caffeine, L-theanine, and Bacopa monnieri.
Chemistry and Physiological Mechanism of Action of BioPerine®
The active ingredient in BioPerine®, piperine, has a long hydrocarbon chain with two aromatic rings, one of which has a nitrogen atom in it. Piperine can interact with a variety of enzymes, receptors, and transporters in the body and brain. This is all thanks to the unique structure of piperine which produced a range of pharmacological effects.
BioPerine® can inhibit drug-metabolizing enzymes like CYP450 and UGTs. By blocking these enzymes, BioPerine® can prolong and increase the plasma concentration of other substances that would otherwise be quickly metabolized and eliminated. Nutrients and supplements like curcumin, resveratrol, and coenzyme Q10, have poor bioavailability or low absorption rates. Therefore, the stated effect is especially significant.
The modulation of neurotransmitters and neuropeptides that control cognitive function, mood, and stress response is also one of the effects of BioPerine®. The release and activity of dopamine, norepinephrine, serotonin, and acetylcholine, which are involved in attention, motivation, memory, and learning, have been all shown to be increased by piperine. Moreover, piperine has been demonstrated to lower cortisol levels, a stress hormone that, when persistently increased, can harm mood and cognitive performance.
Additionally, BioPerine® may exert antioxidant and anti-inflammatory actions, which can protect against oxidative stress and inflammation that are related to aging, dementia, and other chronic disorders. Free radicals are scavenged by piperine; pro-inflammatory cytokines are not produced; antioxidant enzymes like SOD and CAT are more active.
Optimal Dosage of BioPerine®
For the majority, 5–10 mg of BioPerine® per serving, taken with meals or supplements, is the suggested dosage. Going over 20mg of BioPerine® without a doctor’s supervision is not advised. It is significant to note that the ideal dosage of BioPerine® may change based on the bioavailability and dosage of the concurrently supplied nutrients or supplements, as well as on your specific metabolic rate and state of health. As a result, it is advised to talk to a doctor before beginning any supplementing program with BioPerine® or other nootropic products.
Side Effects of BioPerine®
There have been minimal reported negative effects for BioPerine® and hence is usually regarded as safe and well-tolerated. However, some people may encounter mild to moderate gastrointestinal discomfort, including nausea, diarrhea, and stomach pain, particularly at higher doses or when combined with additional vitamins or medications that influence gut motility or absorption. Rarely, some people may be allergic to piperine or black pepper, which could result in skin rashes, irritation, or swelling. It is advised to stop using BioPerine® and get medical help if you experience any negative side effects.
Potential Substance Interactions with BioPerine®
Some medications or dietary supplements that are processed or distributed by the liver or intestines may interact with BioPerine®, including:
1. Substrates for cytochrome P450 (CYP450) enzymes: Warfarin, phenytoin, diazepam, and theophylline are just a few examples of the medications that CYP450 enzymes metabolize. BioPerine® may impede their activity, increasing their plasma concentration and duration as well as their potential toxicity. Hence, it is essential to monitor the dosage and blood levels of these drugs when taken with BioPerine®.
2. Substrates for UDP-glucuronosyltransferases (UGTs): BioPerine® may impede the activity of UGTs, which bind a variety of medications and toxins for elimination, including acetaminophen, bilirubin, and morphine. This could result in lower clearance and possible toxicity or negative consequences. It is advised to keep an eye on the dosage and blood levels of these medications when taken with BioPerine®.
3. Nutrients and supplements: BioPerine® may enhance the absorption and metabolism of many nutrients and supplements, such as curcumin, resveratrol, vitamin C, vitamin B6, and coenzyme Q10, leading to increased plasma concentration and duration of these compounds and potential synergistic or beneficial effects. When combined with BioPerine®, these substances should be monitored for dosage and any interactions, especially if you have any underlying medical conditions or are taking any other medications.
Best Responsible Use of BioPerine®
The best way to use BioPerine® responsibly is to take it as directed, alongside other supplements or prescriptions, and with caution. It’s crucial to select a dependable and high-quality supplier of BioPerine®, such as myPEAK Wellness from myPEAK Supplements, which combines BioPerine® with other nootropic and adaptogenic supplements like Bacopa monnieri, Rhodiola rosea, and Ashwagandha in a synergistic and highly bioavailable formulation. The goal of this formulation is to improve memory, stress tolerance, and cognitive performance while limiting any negative interactions or adverse effects.
Before beginning any supplementing routine with BioPerine® or other nootropic supplements, it is advised to speak with a healthcare practitioner and to adhere to the manufacturer’s instructions and dosage guidelines. To support ideal cognitive performance and general well-being, it is also advised to maintain a healthy lifestyle that includes a balanced diet, regular exercise, and enough sleep.
BioPerine®:
Conclusion
Quality and effective doses of Bioperine® can be found in myPEAK Wellness, a supplement made by MyPEAK supplements. Bioperine® is sourced from Piper nigrum which is very often used in dietary supplements to improve nutrient and supplement absorption, anti-inflammatory and antioxidant effects. It is also a great choice for nootropics if you are seeking to improve your cognition.
We focus on the cognitive enhancing properties of Bioperine® as it is involved in several biochemical pathways that directly increase the levels of neurotransmitters that control learning and memory-forming. Even though it is usually depicted as safe for the majority, you must gauge your supplemental dosage to prevent overdose and always seek medical advice from doctors. You would be able to improve your brain health with continuous use of this product by following the correct guidelines.
References
Molecular and Pharmacological Aspects of Piperine as A Potential Molecule for Disease Prevention and Management: Evidence from Clinical Trials. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796742/#:~:text=Piperine%20is%20a%20type%20of,bioavailability%20and%20fertility%2Drelated%20activities.
Piperine: A Review of Its Biological Effects. Link: https://pubmed.ncbi.nlm.nih.gov/32929825/
Piperine and Its Role in Chronic Diseases. Link: https://pubmed.ncbi.nlm.nih.gov/27671817/
Important Note: The information contained in this article is for general informational purposes only, and should not be construed as health or medical advice, nor is it intended to diagnose, prevent, treat, or cure any disease or health condition. Before embarking on any diet, fitness regimen, or program of nutritional supplementation, it is advisable to consult your healthcare professional in order to determine its safety and probable efficacy in terms of your individual state of health.
Regarding Nutritional Supplements Or Other Non-Prescription Health Products: If any nutritional supplements or other non-prescription health products are mentioned in the foregoing article, any claims or statements made about them have not been evaluated by the U.S. Food and Drug Administration, and such nutritional supplements or other health products are not intended to diagnose, treat, cure, or prevent any disease.
